Download Aging: Facts and Theories by L. Robert, T. Fulop, T. Fulop PDF

By L. Robert, T. Fulop, T. Fulop

Getting older encouraged loads of theories attempting to rationalize the getting older method universal to all residing beings. during this ebook crucial environmental and intrinsic mechanisms keen on the getting older approach and in its pathological results are reviewed. additionally theoretical and experimental facts of crucial theoretical components in line with Darwinian evolution, mobile getting older, function of telephone membranes, unfastened radicals and oxidative strategies, receptor-mediated reactions, the extracellular matrix and immune features in addition to an important environmental and intrinsic mechanisms curious about the getting older technique and in its pathological effects are mentioned. those shows of theories and similar experimental proof supply a world assessment of latest innovations of the biology of the getting older approach and are of crucial interpreting not just for experts during this box but additionally for practitioners of medical, clinical, social and experimental sciences.

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However, for the time being, they are the best product available in the store to explain the existence of the aging process. References 1 Martinez DE: Mortality patterns suggest lack of senescence in hydra. Exp Gerontol 1998;33:217–225. ’ Exp Gerontol 33, 217–225. Exp Gerontol 2010; 45:645–646. 3 Stewart EJ, Madden R, Paul G, Taddei F: Aging and death in an organism that reproduces by morphologically symmetric division. PLoS Biol 2005;3:e45 4 Robertson OH: Prolongation of the life span of kokanee salmon (Oncorhynchus nerka kennerlyi) by castration before beginning of gonad development.

The physiology of the brain represents a pertinent example. Glial cells are fundamental for the survival of the neurons, inter alia through their action on myelination and neuron membrane recycling, creation of the blood brain barrier, control of synapse number, and regulation of the neuron’s ionic environment. Glial cells evolve through the human life span like the fibroblasts with longer division cycles [130] reflecting the metabolic changes they incur through proliferation, which alter their multiple interactions with the neurons and are responsible for many aspects of aging of the brain.

Le Bourg Robert L, Fulop T (eds): Aging: Facts and Theories. Interdiscipl Top Gerontol. 1159/000358897 45 Soerensen M, Dato S, Christensen K, McGue M, Stevnsner T, Bohr VA, Christiansen L: Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data. Aging Cell 2010;9:1010–1017. 46 Tuminello ER, Han SD: The apolipoprotein E antagonistic pleiotropy hypothesis: review and recommendations. Int J Alzheimers Dis 2011;2011:726197. 47 Jochemsen HM, Muller M, van der Graaf Y, Geerlings MI: APOE ε4 differentially influences change in memory performance depending on age.

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